Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines

Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are responsible for cell entry, with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a comprehensive strategy for B cell–based HCV vaccine development through E2 optimization and nanoparticle display. We redesigne...

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Detalles Bibliográficos
Autores principales: He, Linling, Tzarum, Netanel, Lin, Xiaohe, Shapero, Benjamin, Sou, Cindy, Mann, Colin J., Stano, Armando, Zhang, Lei, Nagy, Kenna, Giang, Erick, Law, Mansun, Wilson, Ian A., Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159917/
https://www.ncbi.nlm.nih.gov/pubmed/32494617
http://dx.doi.org/10.1126/sciadv.aaz6225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159917/
https://www.ncbi.nlm.nih.gov/pubmed/32494617
http://dx.doi.org/10.1126/sciadv.aaz6225

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