Sperm DNA damage causes genomic instability in early embryonic development

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiatio...

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Detalles Bibliográficos
Autores principales: Middelkamp, Sjors, van Tol, Helena T. A., Spierings, Diana C. J., Boymans, Sander, Guryev, Victor, Roelen, Bernard A. J., Lansdorp, Peter M., Cuppen, Edwin, Kuijk, Ewart W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159919/
https://www.ncbi.nlm.nih.gov/pubmed/32494621
http://dx.doi.org/10.1126/sciadv.aaz7602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159919/
https://www.ncbi.nlm.nih.gov/pubmed/32494621
http://dx.doi.org/10.1126/sciadv.aaz7602

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