On-chip recapitulation of clinical bone-marrow toxicities and patient-specific pathophysiology

The inaccessibility of living bone marrow hampers the study of its pathophysiology under myelotoxic stress induced by drugs, radiation or genetic mutations. Here, we show that a vascularized human bone-marrow-on-a-chip supports the differentiation and maturation of multiple blood-cell lineages over...

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Detalles Bibliográficos
Autores principales: Chou, David B., Frismantas, Viktoras, Milton, Yuka, David, Rhiannon, Pop-Damkov, Petar, Ferguson, Douglas, MacDonald, Alexander, Bölükbaşı, Özge Vargel, Joyce, Cailin E., Teixeira, Liliana S. Moreira, Rech, Arianna, Jiang, Amanda, Calamari, Elizabeth, Jalili-Firoozinezhad, Sasan, Furlong, Brooke A., O’Sullivan, Lucy R., Ng, Carlos F., Choe, Youngjae, Clauson, Susan, Myers, Kasiani C., Weinberg, Olga K., Hasserjian, Robert P., Novak, Richard, Levy, Oren, Prantil-Baun, Rachelle, Novina, Carl D., Shimamura, Akiko, Ewart, Lorna, Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160021/
https://www.ncbi.nlm.nih.gov/pubmed/31988457
http://dx.doi.org/10.1038/s41551-019-0495-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160021/
https://www.ncbi.nlm.nih.gov/pubmed/31988457
http://dx.doi.org/10.1038/s41551-019-0495-z

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