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Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

Hypoxia (HYPX) induced-overload Ca(2+) entry results in increase of mitochondrial oxidative stress, inflammation and apoptosis in several neurons. Ca(2+) permeable TRPM2 channel was gated by ADP-ribose (ADPR) and reactive oxygen species (ROS), although its activity was modulated in HYPX-exposed neur...

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Detalles Bibliográficos
Autores principales: Akyuva, Yener, Nazıroğlu, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160154/
https://www.ncbi.nlm.nih.gov/pubmed/32296107
http://dx.doi.org/10.1038/s41598-020-63577-5