Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

The DNA methylation regulators DNMT3A and TET2 are recurrently mutated in hematological disorders. Despite possessing antagonistic biochemical activities, loss-of-function murine models show overlapping phenotypes in terms of increased hematopoietic stem cell (HSC) fitness. Here, we directly compare...

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Detalles Bibliográficos
Autores principales: Ostrander, Elizabeth L., Kramer, Ashley C., Mallaney, Cates, Celik, Hamza, Koh, Won Kyun, Fairchild, Jake, Haussler, Emily, Zhang, Christine R.C., Challen, Grant A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160307/
https://www.ncbi.nlm.nih.gov/pubmed/32220332
http://dx.doi.org/10.1016/j.stemcr.2020.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160307/
https://www.ncbi.nlm.nih.gov/pubmed/32220332
http://dx.doi.org/10.1016/j.stemcr.2020.02.011

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