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Memory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment

Hematopoietic stem cells (HSCs) exist in a dormant state and progressively lose regenerative potency as they undergo successive divisions. Why this functional decline occurs and how this information is encoded is unclear. To better understand how this information is stored, we performed RNA sequenci...

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Detalles Bibliográficos
Autores principales: Bernitz, Jeffrey M., Rapp, Katrina, Daniel, Michael G., Shcherbinin, Dmitrii, Yuan, Ye, Gomes, Andreia, Waghray, Avinash, Brosh, Ran, Lachmann, Alexander, Ma'ayan, Avi, Papatsenko, Dmitri, Moore, Kateri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160360/
https://www.ncbi.nlm.nih.gov/pubmed/32243840
http://dx.doi.org/10.1016/j.stemcr.2020.03.005