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Memory of Divisional History Directs the Continuous Process of Primitive Hematopoietic Lineage Commitment
Hematopoietic stem cells (HSCs) exist in a dormant state and progressively lose regenerative potency as they undergo successive divisions. Why this functional decline occurs and how this information is encoded is unclear. To better understand how this information is stored, we performed RNA sequenci...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160360/ https://www.ncbi.nlm.nih.gov/pubmed/32243840 http://dx.doi.org/10.1016/j.stemcr.2020.03.005 |