Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction

The lincosamide family antibiotic lincomycin is a widely used antibacterial pharmaceutical generated by Streptomyces lincolnensis, and the high-yield strain B48 produces 2.5 g/L lincomycin, approximately 30-fold as the wild-type strain NRRL 2936. Here, the genome of S. lincolnensis B48 was completel...

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Detalles Bibliográficos
Autores principales: Wang, Ruida, Kong, Fanjing, Wu, Haizhen, Hou, Bingbing, Kang, Yajing, Cao, Yuan, Duan, Shiwei, Ye, Jiang, Zhang, Huizhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160387/
https://www.ncbi.nlm.nih.gov/pubmed/32322696
http://dx.doi.org/10.1016/j.synbio.2020.03.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160387/
https://www.ncbi.nlm.nih.gov/pubmed/32322696
http://dx.doi.org/10.1016/j.synbio.2020.03.001

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