Triptolide interrupts rRNA synthesis and induces the RPL23-MDM2-p53 pathway to repress lung cancer cells

Lung cancer has one of the highest mortalities of any cancer worldwide. Triptolide (TP) is a promising tumor suppressor extracted from the Chinese herb Tripterygium wilfordii. Our previous proteomics analysis revealed that TP significantly interfered with the ribosome biogenesis pathway; however, th...

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Detalles Bibliográficos
Autores principales: Wang, Juan, Zhang, Zhi-Qian, Li, Fang-Qiong, Chen, Jia-Ning, Gong, Xiaoting, Cao, Bei-Bei, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160537/
https://www.ncbi.nlm.nih.gov/pubmed/32236588
http://dx.doi.org/10.3892/or.2020.7569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160537/
https://www.ncbi.nlm.nih.gov/pubmed/32236588
http://dx.doi.org/10.3892/or.2020.7569

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