CXXC5 Attenuates Pulmonary Fibrosis in a Bleomycin-Induced Mouse Model and MLFs by Suppression of the CD40/CD40L Pathway

OBJECTIVE: To investigate the role of CXXC5 and the CD40/CD40L pathway in lung fibrosis. METHODS: (1) We constructed mouse models of bleomycin-induced pulmonary fibrosis and transfected them with a CXXC5 overexpression vector to evaluate the severity of pulmonary fibrosis. (2) Mouse lung fibroblast...

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Detalles Bibliográficos
Autores principales: Cheng, Wei, Wang, Fangfang, Feng, Airan, Li, Xiaodan, Yu, Wencheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160725/
https://www.ncbi.nlm.nih.gov/pubmed/32337277
http://dx.doi.org/10.1155/2020/7840652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160725/
https://www.ncbi.nlm.nih.gov/pubmed/32337277
http://dx.doi.org/10.1155/2020/7840652

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