Characterizing Interhelical Interactions of G-Protein Coupled Receptors with the Fragment Molecular Orbital Method

[Image: see text] G-protein coupled receptors (GPCRs) are the largest superfamily of membrane proteins, regulating almost every aspect of cellular activity and serving as key targets for drug discovery. We have identified an accurate and reliable computational method to characterize the strength and...

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Detalles Bibliográficos
Autores principales: Heifetz, Alexander, Morao, Inaki, Babu, M. Madan, James, Tim, Southey, Michelle W. Y., Fedorov, Dmitri G., Aldeghi, Matteo, Bodkin, Michael J., Townsend-Nicholson, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161079/
https://www.ncbi.nlm.nih.gov/pubmed/32096994
http://dx.doi.org/10.1021/acs.jctc.9b01136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161079/
https://www.ncbi.nlm.nih.gov/pubmed/32096994
http://dx.doi.org/10.1021/acs.jctc.9b01136

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