Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families

BACKGROUND: Multigene panels are routinely used to assess for predisposing germline mutations in families at high breast cancer risk. The number of variants of unknown significance thereby identified increases with the number of sequenced genes. We aimed to determine whether tumor sequencing can hel...

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Detalles Bibliográficos
Autores principales: Van Marcke, Cédric, Helaers, Raphaël, De Leener, Anne, Merhi, Ahmad, Schoonjans, Céline A., Ambroise, Jérôme, Galant, Christine, Delrée, Paul, Rothé, Françoise, Bar, Isabelle, Khoury, Elsa, Brouillard, Pascal, Canon, Jean-Luc, Vuylsteke, Peter, Machiels, Jean-Pascal, Berlière, Martine, Limaye, Nisha, Vikkula, Miikka, Duhoux, François P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161277/
https://www.ncbi.nlm.nih.gov/pubmed/32295625
http://dx.doi.org/10.1186/s13058-020-01273-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161277/
https://www.ncbi.nlm.nih.gov/pubmed/32295625
http://dx.doi.org/10.1186/s13058-020-01273-y

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