Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma

The alkylating agent cyclophosphamide has been used in the treatment of multiple myeloma for over 60 years. At low doses, cyclophosphamide also has significant immunomodulatory activity, which can be used to modify the immunosuppressive tumor microenvironment in order to augment responses to existin...

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Detalles Bibliográficos
Autores principales: Swan, Dawn, Gurney, Mark, Krawczyk, Janusz, Ryan, Aideen E., O’Dwyer, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162079/
https://www.ncbi.nlm.nih.gov/pubmed/32309787
http://dx.doi.org/10.1097/HS9.0000000000000350
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author Swan, Dawn
Gurney, Mark
Krawczyk, Janusz
Ryan, Aideen E.
O’Dwyer, Michael
author_facet Swan, Dawn
Gurney, Mark
Krawczyk, Janusz
Ryan, Aideen E.
O’Dwyer, Michael
author_sort Swan, Dawn
collection PubMed
description The alkylating agent cyclophosphamide has been used in the treatment of multiple myeloma for over 60 years. At low doses, cyclophosphamide also has significant immunomodulatory activity, which can be used to modify the immunosuppressive tumor microenvironment in order to augment responses to existing therapies. Immune-mediated therapies are becoming more widespread in modern approaches to myeloma treatment. In this review, we discuss the effects cyclophosphamide has on the immune system, and how it can be used synergistically with other treatment modalities including the immunomodulatory agents, monoclonal antibodies and cellular therapies.
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spelling pubmed-71620792020-04-17 Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma Swan, Dawn Gurney, Mark Krawczyk, Janusz Ryan, Aideen E. O’Dwyer, Michael Hemasphere Review Article The alkylating agent cyclophosphamide has been used in the treatment of multiple myeloma for over 60 years. At low doses, cyclophosphamide also has significant immunomodulatory activity, which can be used to modify the immunosuppressive tumor microenvironment in order to augment responses to existing therapies. Immune-mediated therapies are becoming more widespread in modern approaches to myeloma treatment. In this review, we discuss the effects cyclophosphamide has on the immune system, and how it can be used synergistically with other treatment modalities including the immunomodulatory agents, monoclonal antibodies and cellular therapies. Wolters Kluwer Health 2020-04-03 /pmc/articles/PMC7162079/ /pubmed/32309787 http://dx.doi.org/10.1097/HS9.0000000000000350 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Hematology Association. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Review Article
Swan, Dawn
Gurney, Mark
Krawczyk, Janusz
Ryan, Aideen E.
O’Dwyer, Michael
Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title_full Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title_fullStr Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title_full_unstemmed Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title_short Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma
title_sort beyond dna damage: exploring the immunomodulatory effects of cyclophosphamide in multiple myeloma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162079/
https://www.ncbi.nlm.nih.gov/pubmed/32309787
http://dx.doi.org/10.1097/HS9.0000000000000350
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