Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits

Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium channel opener, as a new ocular hypotensive agent...

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Detalles Bibliográficos
Autores principales: Roy Chowdhury, Uttio, Kudgus, Rachel A., Rinkoski, Tommy A., Holman, Bradley H., Bahler, Cindy K., Hann, Cheryl R., Reid, Joel M., Dosa, Peter I., Fautsch, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162492/
https://www.ncbi.nlm.nih.gov/pubmed/32298376
http://dx.doi.org/10.1371/journal.pone.0231841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162492/
https://www.ncbi.nlm.nih.gov/pubmed/32298376
http://dx.doi.org/10.1371/journal.pone.0231841

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