Combining lipoic acid to methylene blue reduces the Warburg effect in CHO cells: From TCA cycle activation to enhancing monoclonal antibody production

The Warburg effect, a hallmark of cancer, has recently been identified as a metabolic limitation of Chinese Hamster Ovary (CHO) cells, the primary platform for the production of monoclonal antibodies (mAb). Metabolic engineering approaches, including genetic modifications and feeding strategies, hav...

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Detalles Bibliográficos
Autores principales: Montégut, Léa, Martínez-Basilio, Pablo César, da Veiga Moreira, Jorgelindo, Schwartz, Laurent, Jolicoeur, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162497/
https://www.ncbi.nlm.nih.gov/pubmed/32298377
http://dx.doi.org/10.1371/journal.pone.0231770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162497/
https://www.ncbi.nlm.nih.gov/pubmed/32298377
http://dx.doi.org/10.1371/journal.pone.0231770

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