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FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks
FANCJ helicase mutations are known to cause hereditary breast and ovarian cancers as well as bone marrow failure syndrome Fanconi anemia. FANCJ plays an important role in the repair of DNA inter-strand crosslinks and DNA double-strand breaks (DSBs) by homologous recombination (HR). Nonetheless, the...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162537/ https://www.ncbi.nlm.nih.gov/pubmed/32251466 http://dx.doi.org/10.1371/journal.pgen.1008701 |