DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

To maintain dNTP pool homeostasis and preserve genetic integrity of nuclear and mitochondrial genomes, the synthesis and degradation of DNA precursors must be precisely regulated. Human all-alpha dCTP pyrophosphatase 1 (DCTPP1) is a dNTP pyrophosphatase with high affinity for dCTP and 5′-modified dC...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez-Arribas, Blanca, Requena, Cristina E., Pérez-Moreno, Guiomar, Ruíz-Pérez, Luis M., Vidal, Antonio E., González-Pacanowska, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162842/
https://www.ncbi.nlm.nih.gov/pubmed/31377845
http://dx.doi.org/10.1007/s00018-019-03250-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162842/
https://www.ncbi.nlm.nih.gov/pubmed/31377845
http://dx.doi.org/10.1007/s00018-019-03250-x

Ejemplares similares