Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma

Glioblastoma, the most lethal primary brain cancer, is extremely proliferative and invasive. Tumor cells at tumor/brain-interface often exist behind a functionally intact blood-brain barrier (BBB), and so are shielded from exposure to therapeutic drug concentrations. An ideal glioblastoma treatment...

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Detalles Bibliográficos
Autores principales: Gampa, Gautham, Kenchappa, Rajappa S., Mohammad, Afroz S., Parrish, Karen E., Kim, Minjee, Crish, James F., Luu, Amanda, West, Rita, Hinojosa, Alfredo Quinones, Sarkaria, Jann N., Rosenfeld, Steven S., Elmquist, William F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162859/
https://www.ncbi.nlm.nih.gov/pubmed/32300151
http://dx.doi.org/10.1038/s41598-020-63494-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162859/
https://www.ncbi.nlm.nih.gov/pubmed/32300151
http://dx.doi.org/10.1038/s41598-020-63494-7

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