A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer therapy. Several tumors excessively metabolize glutamine to generate precursors for...

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Detalles Bibliográficos
Autores principales: Koch, Katharina, Hartmann, Rudolf, Tsiampali, Julia, Uhlmann, Constanze, Nickel, Ann-Christin, He, Xiaoling, Kamp, Marcel A., Sabel, Michael, Barker, Roger A., Steiger, Hans-Jakob, Hänggi, Daniel, Willbold, Dieter, Maciaczyk, Jaroslaw, Kahlert, Ulf D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162917/
https://www.ncbi.nlm.nih.gov/pubmed/32337072
http://dx.doi.org/10.1038/s41420-020-0258-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162917/
https://www.ncbi.nlm.nih.gov/pubmed/32337072
http://dx.doi.org/10.1038/s41420-020-0258-3

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