Understanding the drug exposure–response relationship of bedaquiline to predict efficacy for novel dosing regimens in the treatment of multidrug‐resistant tuberculosis

AIMS: To externally validate an earlier characterized relationship between bedaquiline exposure and decline in bacterial load in a more difficult‐to‐treat patient population, and to explore the performances of alternative dosing regimens through simulations. METHODS: The bedaquiline exposure–respons...

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Detalles Bibliográficos
Autores principales: Tanneau, Lénaïg, Karlsson, Mats O., Svensson, Elin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163373/
https://www.ncbi.nlm.nih.gov/pubmed/31840278
http://dx.doi.org/10.1111/bcp.14199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163373/
https://www.ncbi.nlm.nih.gov/pubmed/31840278
http://dx.doi.org/10.1111/bcp.14199

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