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Understanding the drug exposure–response relationship of bedaquiline to predict efficacy for novel dosing regimens in the treatment of multidrug‐resistant tuberculosis
AIMS: To externally validate an earlier characterized relationship between bedaquiline exposure and decline in bacterial load in a more difficult‐to‐treat patient population, and to explore the performances of alternative dosing regimens through simulations. METHODS: The bedaquiline exposure–respons...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163373/ https://www.ncbi.nlm.nih.gov/pubmed/31840278 http://dx.doi.org/10.1111/bcp.14199 |