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NTRK fusions in osteosarcoma are rare and non‐functional events

Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a low prev...

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Detalles Bibliográficos
Autores principales: Ameline, Baptiste, Saba, Karim H, Kovac, Michal, Magnusson, Linda, Witt, Olaf, Bielack, Stefan, Nathrath, Michaela, Nord, Karolin H, Baumhoer, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164374/
https://www.ncbi.nlm.nih.gov/pubmed/32022484
http://dx.doi.org/10.1002/cjp2.158