An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Herein, we show that the ribonucleoside analog β-D-N(4)-hydroxycytidine (NHC, EIDD-1931) has broad spectrum antivi...

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Detalles Bibliográficos
Autores principales: Sheahan, Timothy P., Sims, Amy C., Zhou, Shuntai, Graham, Rachel L., Pruijssers, Andrea J., Agostini, Maria L., Leist, Sarah R., Schäfer, Alexandra, Dinnon, Kenneth H., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., George, Amelia S., Hill, Collin S., Montgomery, Stephanie A., Brown, Ariane J., Bluemling, Gregory R., Natchus, Michael G., Saindane, Manohar, Kolykhalov, Alexander A., Painter, George, Harcourt, Jennifer, Tamin, Azaibi, Thornburg, Natalie J., Swanstrom, Ronald, Denison, Mark R., Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164393/
https://www.ncbi.nlm.nih.gov/pubmed/32253226
http://dx.doi.org/10.1126/scitranslmed.abb5883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164393/
https://www.ncbi.nlm.nih.gov/pubmed/32253226
http://dx.doi.org/10.1126/scitranslmed.abb5883

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