Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway. Diacylglycerol (DA...

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Detalles Bibliográficos
Autores principales: Nosbisch, Jamie L., Rahman, Anisur, Mohan, Krithika, Elston, Timothy C., Bear, James E., Haugh, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164671/
https://www.ncbi.nlm.nih.gov/pubmed/32255775
http://dx.doi.org/10.1371/journal.pcbi.1007708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164671/
https://www.ncbi.nlm.nih.gov/pubmed/32255775
http://dx.doi.org/10.1371/journal.pcbi.1007708

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