Cargando…

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/protein kinase C (PKC) pathway. Diacylglycerol (DA...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nosbisch, Jamie L., Rahman, Anisur, Mohan, Krithika, Elston, Timothy C., Bear, James E., Haugh, Jason M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164671/ https://www.ncbi.nlm.nih.gov/pubmed/32255775 http://dx.doi.org/10.1371/journal.pcbi.1007708

Ejemplares similares

A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation
por: Nosbisch, Jamie L., et al.
Publicado: (2022)

On the efficiency of chemotactic pursuit - Comparing blind search with temporal and spatial gradient sensing
por: Metzner, Claus
Publicado: (2019)

Testing the limits of gradient sensing
por: Lakhani, Vinal, et al.
Publicado: (2017)

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
por: Zhu, Meng, et al.
Publicado: (2017)

Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
por: Kim, Jin-Man, et al.
Publicado: (2018)

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors
Publicado: (1977)

Calretinin Participates in Regulating Steroidogenesis by PLC-Ca(2+)-PKC Pathway in Leydig Cells
por: Xu, Wendan, et al.
Publicado: (2018)

Diacylglycerol Kinases: Shaping Diacylglycerol and Phosphatidic Acid Gradients to Control Cell Polarity
por: Baldanzi, Gianluca, et al.
Publicado: (2016)

Structural Basis of Phosphatidic Acid Sensing by APH in Apicomplexan Parasites
por: Darvill, Nick, et al.
Publicado: (2018)

Mechanistic modeling of light-induced chemotactic infiltration of bacteria into leaf stomata
por: Ranjbaran, Mohsen, et al.
Publicado: (2020)

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition
por: Chen, Jing, et al.
Publicado: (2018)

Roles and mechanisms of TRPC3 and the PLCγ/PKC/CPI-17 signaling pathway in regulating parturition
por: Chen, Jing, et al.
Publicado: (2018)

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients
por: Heit, Bryan, et al.
Publicado: (2002)

Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient
por: Liu, Xiaowen, et al.
Publicado: (2015)

LPP3, LPA and self-generated chemotactic gradients in biomedical science
por: Susanto, Olivia, et al.
Publicado: (2017)

Chemotactic Responses of Jurkat Cells in Microfluidic Flow-Free Gradient Chambers
por: Sonmez, Utku M., et al.
Publicado: (2020)

New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein
por: Sakane, Fumio, et al.
Publicado: (2020)

Effect of oral administration of soy-derived phosphatidic acid on concentrations of phosphatidic acid and lyso-phosphatidic acid molecular species in human plasma
por: Purpura, Martin, et al.
Publicado: (2013)

PKCδ Localization at the Membrane Increases Matrix Traction Force Dependent on PLCγ1/EGFR Signaling
por: Jamison, Joshua, et al.
Publicado: (2013)

Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways
por: Yen, Ting-Lin, et al.
Publicado: (2014)

The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of Neutrophils
por: Xu, Xuehua, et al.
Publicado: (2015)

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells
por: Susanto, Olivia, et al.
Publicado: (2017)

Chemotactic responses of growing neurites to precisely controlled gradients of nerve growth factor
por: Bicknell, Brendan A., et al.
Publicado: (2018)

Tortoise, a Novel Mitochondrial Protein, Is Required for Directional Responses of Dictyostelium in Chemotactic Gradients
por: van Es, Saskia, et al.
Publicado: (2001)

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal
por: Muinonen-Martin, Andrew J., et al.
Publicado: (2014)

Migration of mesenchymal stem cells tethered with carbon nanotubes under a chemotactic gradient
por: Zhang, Jun, et al.
Publicado: (2019)

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis
por: Xu, Xuehua, et al.
Publicado: (2015)

PDGF-BB enhances collagen gel contraction through a PI3K-PLCγ-PKC-cofilin pathway
por: Reyhani, Vahid, et al.
Publicado: (2017)

Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways
por: Lien, Li-Ming, et al.
Publicado: (2017)

Role of PKCδ in Enhanced Expression of Gqα/PLCβ1 Proteins and VSMC Hypertrophy in Spontaneously Hypertensive Rats
por: Atef, Mohammed Emehdi, et al.
Publicado: (2016)

Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets
por: Hsia, Chih-Wei, et al.
Publicado: (2019)

Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway
por: Yi, Genzheng, et al.
Publicado: (2022)

Phosphatidic acid, phospholipase D and tumorigenesis(☆)
por: Gomez-Cambronero, Julian
Publicado: (2013)

Optical Control of Phosphatidic Acid Signaling
por: Tei, Reika, et al.
Publicado: (2021)

Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils
Publicado: (1995)

SET/PP2A signaling regulates macrophage positioning in hypoxic tumor regions by amplifying chemotactic responses
por: Zhang, Shaolong, et al.
Publicado: (2022)

Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts
por: Schneider, Ian C., et al.
Publicado: (2005)

Edema Induced by a Crotalus durissus terrificus Venom Serine Protease (Cdtsp 2) Involves the PAR Pathway and PKC and PLC Activation
por: Costa, Caroline R. C., et al.
Publicado: (2018)

The RXFP2-PLC/PKC signaling pathway mediates INSL3-induced regulation of the proliferation, migration and apoptosis of mouse gubernacular cells
por: Duan, Shouxing, et al.
Publicado: (2023)

LPA(2) Alleviates Septic Acute Lung Injury via Protective Endothelial Barrier Function Through Activation of PLC-PKC-FAK
por: Bai, Ruifeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ifmbcsel2p3lml9gi6tiapr5af