A novel landscape of nuclear human CDK2 substrates revealed by in situ phosphorylation

Cyclin-dependent kinase 2 (CDK2) controls cell division and is central to oncogenic signaling. We used an “in situ” approach to identify CDK2 substrates within nuclei isolated from cells expressing CDK2 engineered to use adenosine 5′-triphosphate analogs. We identified 117 candidate substrates, ~40%...

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Detalles Bibliográficos
Autores principales: Chi, Yong, Carter, John H., Swanger, Jherek, Mazin, Alexander V., Moritz, Robert L., Clurman, Bruce E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164936/
https://www.ncbi.nlm.nih.gov/pubmed/32494624
http://dx.doi.org/10.1126/sciadv.aaz9899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164936/
https://www.ncbi.nlm.nih.gov/pubmed/32494624
http://dx.doi.org/10.1126/sciadv.aaz9899

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