Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide the engineering of an alcohol dehydrogenase....

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Detalles Bibliográficos
Autores principales: Aalbers, Friso S, Fürst, Maximilian JLJ, Rovida, Stefano, Trajkovic, Milos, Gómez Castellanos, J Rubén, Bartsch, Sebastian, Vogel, Andreas, Mattevi, Andrea, Fraaije, Marco W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164962/
https://www.ncbi.nlm.nih.gov/pubmed/32228861
http://dx.doi.org/10.7554/eLife.54639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164962/
https://www.ncbi.nlm.nih.gov/pubmed/32228861
http://dx.doi.org/10.7554/eLife.54639

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