Cancer epithelia-derived mitochondrial DNA is a targetable initiator of a paracrine signaling loop that confers taxane resistance

Stromal-epithelial interactions dictate cancer progression and therapeutic response. Prostate cancer (PCa) cells were identified to secrete greater concentration of mitochondrial DNA (mtDNA) compared to noncancer epithelia. Based on the recognized coevolution of cancer-associated fibroblasts (CAF) w...

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Detalles Bibliográficos
Autores principales: Haldar, Subhash, Mishra, Rajeev, Billet, Sandrine, Thiruvalluvan, Manish, Placencio-Hickok, Veronica R., Madhav, Anisha, Duong, Frank, Angara, Bryan, Agarwal, Priyanka, Tighiouart, Mourad, Posadas, Edwin M., Bhowmick, Neil A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165425/
https://www.ncbi.nlm.nih.gov/pubmed/32238563
http://dx.doi.org/10.1073/pnas.1910952117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165425/
https://www.ncbi.nlm.nih.gov/pubmed/32238563
http://dx.doi.org/10.1073/pnas.1910952117

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