Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells

Dicer is a ribonuclease III enzyme in biosynthesis of micro-RNAs (miRNAs). Here we describe a regulation of Dicer expression in monocytic cells, based on proteolysis. In undifferentiated Mono Mac 6 (MM6) cells, full-length Dicer was undetectable; only an ∼50-kDa fragment appeared in Western blots. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Basavarajappa, Devaraj, Uebbing, Stella, Kreiss, Marius, Lukic, Ana, Suess, Beatrix, Steinhilber, Dieter, Samuelsson, Bengt, Rådmark, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165444/
https://www.ncbi.nlm.nih.gov/pubmed/32220961
http://dx.doi.org/10.1073/pnas.1916249117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165444/
https://www.ncbi.nlm.nih.gov/pubmed/32220961
http://dx.doi.org/10.1073/pnas.1916249117

Ejemplares similares