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Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest
In bacteria, the first two steps of gene expression—transcription and translation—are spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double-stranded breaks and genomic i...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165469/ https://www.ncbi.nlm.nih.gov/pubmed/32238560 http://dx.doi.org/10.1073/pnas.1919985117 |