Cargando…

Ribosome reactivates transcription by physically pushing RNA polymerase out of transcription arrest

In bacteria, the first two steps of gene expression—transcription and translation—are spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double-stranded breaks and genomic i...

Descripción completa

Detalles Bibliográficos
Autores principales: Stevenson-Jones, Flint, Woodgate, Jason, Castro-Roa, Daniel, Zenkin, Nikolay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165469/
https://www.ncbi.nlm.nih.gov/pubmed/32238560
http://dx.doi.org/10.1073/pnas.1919985117

Ejemplares similares