Modified nucleotides may have enhanced early RNA catalysis

The modern version of the RNA World Hypothesis begins with activated ribonucleotides condensing (nonenzymatically) to make RNA molecules, some of which possess (perhaps slight) catalytic activity. We propose that noncanonical ribonucleotides, which would have been inevitable under prebiotic conditio...

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Detalles Bibliográficos
Autores principales: Wolk, Steven K., Mayfield, Wesley S., Gelinas, Amy D., Astling, David, Guillot, Jessica, Brody, Edward N., Janjic, Nebojsa, Gold, Larry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165471/
https://www.ncbi.nlm.nih.gov/pubmed/32229566
http://dx.doi.org/10.1073/pnas.1809041117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165471/
https://www.ncbi.nlm.nih.gov/pubmed/32229566
http://dx.doi.org/10.1073/pnas.1809041117

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