MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease

Polyglutamine (polyQ) tract expansion leads to proteotoxic misfolding and drives a family of nine diseases. We study spinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder of the neuromuscular system caused by the polyQ androgen receptor (AR). Using a knock-in mouse model of...

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Detalles Bibliográficos
Autores principales: Nath, Samir R., Lieberman, Matthew L., Yu, Zhigang, Marchioretti, Caterina, Jones, Samuel T., Danby, Emily C. E., Van Pelt, Kate M., Sorarù, Gianni, Robins, Diane M., Bates, Gillian P., Pennuto, Maria, Lieberman, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166004/
https://www.ncbi.nlm.nih.gov/pubmed/32306066
http://dx.doi.org/10.1007/s00401-020-02156-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166004/
https://www.ncbi.nlm.nih.gov/pubmed/32306066
http://dx.doi.org/10.1007/s00401-020-02156-4

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