The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling

BACKGROUND AND OBJECTIVES: Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials on patients with special diseases. In this study, simulations were carried out to validate the pharmacokinetic parameters of clozapine and...

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Detalles Bibliográficos
Autores principales: Ghoneim, Amira M, Mansour, Suzan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166056/
https://www.ncbi.nlm.nih.gov/pubmed/32341640
http://dx.doi.org/10.2147/DDDT.S246229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166056/
https://www.ncbi.nlm.nih.gov/pubmed/32341640
http://dx.doi.org/10.2147/DDDT.S246229

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