Mixture of MMP-2, MLC, and NOS Inhibitors Affects NO Metabolism and Protects Heart from Cardiac I/R Injury

OBJECTIVES: Coronary reperfusion procedure leads to ischemia/reperfusion injury of the heart (IRI). IRI arises from increased degradation of myosin light chains and increased activity of matrix metalloproteinase 2 (MMP-2). Increased production of toxic peroxynitrite (ONOO(−)) during oxidative stress...

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Detalles Bibliográficos
Autores principales: Krzywonos-Zawadzka, Anna, Franczak, Aleksandra, Sawicki, Grzegorz, Bil-Lula, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166281/
https://www.ncbi.nlm.nih.gov/pubmed/32322413
http://dx.doi.org/10.1155/2020/1561478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166281/
https://www.ncbi.nlm.nih.gov/pubmed/32322413
http://dx.doi.org/10.1155/2020/1561478

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