Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7

Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (Na(V)). Here, we describe the discovery of μ-theraphotoxin-Pme1a and μ/δ-theraphotoxin-Pme2a, two novel peptides from the venom of the Gooty Ornamental tarantula Poecilother...

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Detalles Bibliográficos
Autores principales: Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker, Vetter, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167818/
https://www.ncbi.nlm.nih.gov/pubmed/32092883
http://dx.doi.org/10.3390/biomedicines8020037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167818/
https://www.ncbi.nlm.nih.gov/pubmed/32092883
http://dx.doi.org/10.3390/biomedicines8020037

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