Cargando…
Addition of K22 Converts Spider Venom Peptide Pme2a from an Activator to an Inhibitor of Na(V)1.7
Spider venom is a novel source of disulfide-rich peptides with potent and selective activity at voltage-gated sodium channels (Na(V)). Here, we describe the discovery of μ-theraphotoxin-Pme1a and μ/δ-theraphotoxin-Pme2a, two novel peptides from the venom of the Gooty Ornamental tarantula Poecilother...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167818/ https://www.ncbi.nlm.nih.gov/pubmed/32092883 http://dx.doi.org/10.3390/biomedicines8020037 |