The Cell-Cycle Regulatory Protein p21(CIP1/WAF1) Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21(CIP1/WAF1) is critical to Cdt-induced apoptosis. Cdt induces increases in t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shenker, Bruce J., Walker, Lisa M., Zekavat, Ali, Weiss, Robert H., Boesze-Battaglia, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168616/
https://www.ncbi.nlm.nih.gov/pubmed/31906446
http://dx.doi.org/10.3390/pathogens9010038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168616/
https://www.ncbi.nlm.nih.gov/pubmed/31906446
http://dx.doi.org/10.3390/pathogens9010038

Ejemplares similares