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The Cell-Cycle Regulatory Protein p21(CIP1/WAF1) Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis

The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21(CIP1/WAF1) is critical to Cdt-induced apoptosis. Cdt induces increases in t...

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Detalles Bibliográficos
Autores principales:	Shenker, Bruce J., Walker, Lisa M., Zekavat, Ali, Weiss, Robert H., Boesze-Battaglia, Kathleen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168616/ https://www.ncbi.nlm.nih.gov/pubmed/31906446 http://dx.doi.org/10.3390/pathogens9010038

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