Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes

Leukotoxin (LtxA), from oral pathogen Aggregatibacter actinomycetemcomitans, is a secreted membrane-damaging protein. LtxA is internalized by β2 integrin LFA-1 (CD11a/CD18)-expressing leukocytes and ultimately causes cell death; however, toxin localization in the host cell is poorly understood and t...

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Detalles Bibliográficos
Autores principales: Lally, Edward T, Boesze-Battaglia, Kathleen, Dhingra, Anuradha, Gomez, Nestor M, Lora, Jinery, Mitchell, Claire H, Giannakakis, Alexander, Fahim, Syed A, Benz, Roland, Balashova, Nataliya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168647/
https://www.ncbi.nlm.nih.gov/pubmed/31973183
http://dx.doi.org/10.3390/pathogens9020074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168647/
https://www.ncbi.nlm.nih.gov/pubmed/31973183
http://dx.doi.org/10.3390/pathogens9020074

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