Cargando…

Aggregatibacter actinomycetemcomitans LtxA Hijacks Endocytic Trafficking Pathways in Human Lymphocytes

Leukotoxin (LtxA), from oral pathogen Aggregatibacter actinomycetemcomitans, is a secreted membrane-damaging protein. LtxA is internalized by β2 integrin LFA-1 (CD11a/CD18)-expressing leukocytes and ultimately causes cell death; however, toxin localization in the host cell is poorly understood and t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lally, Edward T, Boesze-Battaglia, Kathleen, Dhingra, Anuradha, Gomez, Nestor M, Lora, Jinery, Mitchell, Claire H, Giannakakis, Alexander, Fahim, Syed A, Benz, Roland, Balashova, Nataliya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168647/ https://www.ncbi.nlm.nih.gov/pubmed/31973183 http://dx.doi.org/10.3390/pathogens9020074

Ejemplares similares

Membrane localization of the Repeats-in-Toxin (RTX) Leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans
por: Brown, Angela C., et al.
Publicado: (2018)

Gangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis
por: Forman, Michael S., et al.
Publicado: (2010)

Aggregatibacter actinomycetemcomitans Leukotoxin (LtxA; Leukothera(®)): Mechanisms of Action and Therapeutic Applications
por: Vega, Brian A., et al.
Publicado: (2019)

Internalization and Intoxication of Human Macrophages by the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent Upon Cellugyrin (Synaptogyrin-2)
por: Boesze-Battaglia, Kathleen, et al.
Publicado: (2020)

Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function
por: Kim, Taewan J., et al.
Publicado: (2023)

Aggregatibacter actinomycetemcomitans Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles
por: Nice, Justin B., et al.
Publicado: (2018)

Corrigendum: Aggregatibacter actinomycetemcomitans cytolethal distending toxin modulates host phagocytic function
por: Kim, Taewan J., et al.
Publicado: (2023)

Internalization of the Active Subunit of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Is Dependent upon Cellugyrin (Synaptogyrin 2), a Host Cell Non-Neuronal Paralog of the Synaptic Vesicle Protein, Synaptogyrin 1
por: Boesze-Battaglia, Kathleen, et al.
Publicado: (2017)

Leukotoxin (LtxA/Leukothera) induces ATP expulsion via pannexin-1 channels and subsequent cell death in malignant lymphocytes
por: Prince, Derek J., et al.
Publicado: (2021)

Proteomics of Protein Secretion by Aggregatibacter actinomycetemcomitans
por: Zijnge, Vincent, et al.
Publicado: (2012)

Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans
por: Belibasakis, Georgios N., et al.
Publicado: (2019)

Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin-Induces Cell Cycle Arrest in a Glycogen Synthase Kinase (GSK)-3-Dependent Manner in Oral Keratinocytes
por: Shenker, Bruce J., et al.
Publicado: (2022)

HIV Envelope gp120 Activates LFA-1 on CD4 T-Lymphocytes and Increases Cell Susceptibility to LFA-1-Targeting Leukotoxin (LtxA)
por: Hioe, Catarina E., et al.
Publicado: (2011)

Proteomics of Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles
por: Kieselbach, Thomas, et al.
Publicado: (2015)

Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells()
por: Dietmann, Anelia, et al.
Publicado: (2013)

Modulation of neutrophil chemotaxis by Aggregatibacter actinomycetemcomitans leukotoxin
por: Hirschfeld, Josefine, et al.
Publicado: (2017)

The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis
por: Johansson, Anders, et al.
Publicado: (2017)

Tools of Aggregatibacter actinomycetemcomitans to Evade the Host Response
por: Oscarsson, Jan, et al.
Publicado: (2019)

Characterization of the L-Lactate Dehydrogenase from Aggregatibacter actinomycetemcomitans
por: Brown, Stacie A., et al.
Publicado: (2009)

Leukotoxic Activity of Aggregatibacter actinomycetemcomitans and Periodontal Attachment Loss
por: Höglund Åberg, Carola, et al.
Publicado: (2014)

Differential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes
por: Umeda, Josely Emiko, et al.
Publicado: (2013)

Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans
por: Oogai, Yuichi, et al.
Publicado: (2018)

Antimicrobial susceptibility pattern of oral isolates of Aggregatibacter actinomycetemcomitans
por: Bhat, Kishore G, et al.
Publicado: (2019)

Cranberry Proanthocyanidins Neutralize the Effects of Aggregatibacter actinomycetemcomitans Leukotoxin
por: Ben Lagha, Amel, et al.
Publicado: (2019)

Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8
por: Ahlstrand, Tuuli, et al.
Publicado: (2018)

Antibiotic susceptibility of Aggregatibacter actinomycetemcomitans JP2 in a biofilm
por: Oettinger-Barak, Orit, et al.
Publicado: (2013)

A case of Aggregatibacter actinomycetemcomitans endocarditis presenting as quadriceps myositis
por: Reid, Angeline, et al.
Publicado: (2012)

Alteration of Homeostasis in Pre-osteoclasts Induced by Aggregatibacter actinomycetemcomitans CDT
por: Kawamoto, Dione, et al.
Publicado: (2016)

Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis
por: Åberg, Carola Höglund, et al.
Publicado: (2014)

Complete Genome Sequence of Aggregatibacter actinomycetemcomitans Strain IDH781
por: May, Anthony C., et al.
Publicado: (2016)

Himar1 Transposon for Efficient Random Mutagenesis in Aggregatibacter actinomycetemcomitans
por: Ding, Qinfeng, et al.
Publicado: (2017)

In vitro effect of diode laser against biofilm of Aggregatibacter actinomycetemcomitans
por: Tantivitayakul, Ponpen, et al.
Publicado: (2018)

Phosphorylcholine is located in Aggregatibacter actinomycetemcomitans fimbrial protein Flp 1
por: Ihalin, Riikka, et al.
Publicado: (2018)

Aggregatibacter actinomycetemcomitans Induces Autophagy in Human Junctional Epithelium Keratinocytes
por: Vicencio, Emiliano, et al.
Publicado: (2020)

Outer membrane vesicle-mediated serum protection in Aggregatibacter actinomycetemcomitans
por: Lindholm, Mark, et al.
Publicado: (2020)

Aggregatibacter actinomycetemcomitans Causing Empyema Necessitans and Pyomyositis in an Immunocompetent Patient
por: Homsi, Nora, et al.
Publicado: (2020)

Rheumatoid Arthritis-Associated Mechanisms of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
por: Gómez-Bañuelos, Eduardo, et al.
Publicado: (2019)

Antimicrobial Activity of Roselle-capped Silver Nanochip on Aggregatibacter actinomycetemcomitans
por: Wacharanad, Sirorat, et al.
Publicado: (2021)

Resolvin E1's Antimicrobial Potential Against Aggregatibacter Actinomycetemcomitans
por: Abdullatif, Fahad A., et al.
Publicado: (2022)

Differential Virulence of Aggregatibacter actinomycetemcomitans Serotypes Explained by Exoproteome Heterogeneity
por: Fu, Yanyan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_v0mkuj5ta90qc6qjse7d9ri5s3