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Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A Review

It is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies. Microtubules are predominantly composed of the protein tubulin, which contains a number of different binding sites for small-molecule drugs. There is contin...

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Detalles Bibliográficos
Autores principales: McLoughlin, Eavan C., O’Boyle, Niamh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168938/
https://www.ncbi.nlm.nih.gov/pubmed/31947889
http://dx.doi.org/10.3390/ph13010008