Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model

P-cadherin-LP-DART is a bispecific antibody targeting P-cadherin expressed on the tumor cells and CD3 on the T-cells. Previously we demonstrated the development and efficacy of P-cadherin-LP-DART in in vitro and in vivo models. Here, we evaluated the three pillars: exposure, targeting specificity an...

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Detalles Bibliográficos
Autores principales: Gupta, Vijay R., Root, Adam, Fisher, Timothy, Norberg, Rand, David, John, Clark, Tracey, Cohen, Justin, May, Chad, Giddabasappa, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170501/
https://www.ncbi.nlm.nih.gov/pubmed/32341754
http://dx.doi.org/10.18632/oncotarget.27544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170501/
https://www.ncbi.nlm.nih.gov/pubmed/32341754
http://dx.doi.org/10.18632/oncotarget.27544

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