Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fe...

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Detalles Bibliográficos
Autores principales: Shen, Yaoyao, Sun, Fan, Zhang, Liu, Cheng, Yijia, Zhu, Hongrui, Wang, Shu-Ping, Jiao, Wei-Hua, Leadlay, Peter F., Zhou, Yongjun, Lin, Hou-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170507/
https://www.ncbi.nlm.nih.gov/pubmed/32165500
http://dx.doi.org/10.1074/jbc.RA119.010922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170507/
https://www.ncbi.nlm.nih.gov/pubmed/32165500
http://dx.doi.org/10.1074/jbc.RA119.010922

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