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Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase

Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS), typically from the starting precursor 3-formamidosalicylate. Examining fe...

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Detalles Bibliográficos
Autores principales:	Shen, Yaoyao, Sun, Fan, Zhang, Liu, Cheng, Yijia, Zhu, Hongrui, Wang, Shu-Ping, Jiao, Wei-Hua, Leadlay, Peter F., Zhou, Yongjun, Lin, Hou-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170507/ https://www.ncbi.nlm.nih.gov/pubmed/32165500 http://dx.doi.org/10.1074/jbc.RA119.010922

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