Salvianolic Acid Alleviated Blood–Brain Barrier Permeability in Spontaneously Hypertensive Rats by Inhibiting Apoptosis in Pericytes via P53 and the Ras/Raf/MEK/ERK Pathway

OBJECTIVE: To investigate the effect of salvianolic acid A (SA) on the permeability of blood–brain barrier (BBB) and brain microvascular pericyte apoptosis in spontaneously hypertensive rats (SHR). METHODS: Evans Blue was used to determine the BBB permeability in control rats and SHR. Western blotti...

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Detalles Bibliográficos
Autores principales: Wu, Qingbin, Yuan, Xiaochen, Li, Bingwei, Han, Ruiqin, Zhang, Honggang, Xiu, Ruijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170553/
https://www.ncbi.nlm.nih.gov/pubmed/32368011
http://dx.doi.org/10.2147/DDDT.S245959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170553/
https://www.ncbi.nlm.nih.gov/pubmed/32368011
http://dx.doi.org/10.2147/DDDT.S245959

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