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Theoretical relation between axon initial segment geometry and excitability

In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial segment (AIS). Both position and length of the AIS vary across and within neuron types, with activity, development and pathology. What is the impact of AIS geometry on excitability? Direct empirical ass...

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Detalles Bibliográficos
Autores principales: Goethals, Sarah, Brette, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170651/
https://www.ncbi.nlm.nih.gov/pubmed/32223890
http://dx.doi.org/10.7554/eLife.53432