A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models

Oncolytic viruses have shown excellent safety profiles in preclinical and clinical studies; however, in most cases therapeutic benefits have been modest. We have previously reported the generation of a chimeric poxvirus (CF33), with significantly improved oncolytic characteristics, through chimeriza...

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Detalles Bibliográficos
Autores principales: Chaurasiya, Shyambabu, Chen, Nanhai G., Lu, Jianming, Martin, Nikolas, Shen, Yinan, Kim, Sang-In, Warner, Susanne G., Woo, Yanghee, Fong, Yuman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170804/
https://www.ncbi.nlm.nih.gov/pubmed/31209267
http://dx.doi.org/10.1038/s41417-019-0114-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170804/
https://www.ncbi.nlm.nih.gov/pubmed/31209267
http://dx.doi.org/10.1038/s41417-019-0114-x

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