Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis

To achieve productive binding, enzymes and substrates must align their geometries to complement each other along an entire substrate binding site, which may require enzyme flexibility. In pursuit of novel drug targets for the human pathogen S. aureus, we studied peptidoglycan N-acetylglucosaminidase...

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Detalles Bibliográficos
Autores principales: Pintar, Sara, Borišek, Jure, Usenik, Aleksandra, Perdih, Andrej, Turk, Dušan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170848/
https://www.ncbi.nlm.nih.gov/pubmed/32313083
http://dx.doi.org/10.1038/s42003-020-0911-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170848/
https://www.ncbi.nlm.nih.gov/pubmed/32313083
http://dx.doi.org/10.1038/s42003-020-0911-7

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