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Large scale active-learning-guided exploration for in vitro protein production optimization

Lysate-based cell-free systems have become a major platform to study gene expression but batch-to-batch variation makes protein production difficult to predict. Here we describe an active learning approach to explore a combinatorial space of ~4,000,000 cell-free buffer compositions, maximizing prote...

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Detalles Bibliográficos
Autores principales: Borkowski, Olivier, Koch, Mathilde, Zettor, Agnès, Pandi, Amir, Batista, Angelo Cardoso, Soudier, Paul, Faulon, Jean-Loup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170859/
https://www.ncbi.nlm.nih.gov/pubmed/32312991
http://dx.doi.org/10.1038/s41467-020-15798-5