Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells

Impairment of mitochondrial structure and function is strongly linked to glaucoma pathogenesis. Despite the widely appreciated disease relevance of mitochondrial dysfunction and loss, the molecular mechanisms underlying mitochondrial fragmentation and metabolic stress in glaucoma are poorly understo...

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Detalles Bibliográficos
Autores principales: Edwards, Genea, Perkins, Guy A., Kim, Keun-Young, Kong, YeEun, Lee, Yonghoon, Choi, Soo-Ho, Liu, Yujia, Skowronska-Krawczyk, Dorota, Weinreb, Robert N., Zangwill, Linda, Strack, Stefan, Ju, Won-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170863/
https://www.ncbi.nlm.nih.gov/pubmed/32312949
http://dx.doi.org/10.1038/s41419-020-2456-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170863/
https://www.ncbi.nlm.nih.gov/pubmed/32312949
http://dx.doi.org/10.1038/s41419-020-2456-6

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